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KMID : 1134820190480030297
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 3 p.297 ~ p.305
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Grape Seed Extract Complex (FFM-GS) Inhibits Postmenopausal Symptoms: In Vitro and In Vivo Study
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Lee Min-Hee
Nam Da-Eun
Park Soo-Jeung
Kim Da-Kyung
Yun Jeong-Moon
Kim Ok-Kyung
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Abstract
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This study examined the effects of grape (Vitis vinifera L.) seed, valerian (Valeriana officinalis), and safflower (Carthamus tinctorius) seed extract complex (grape seed extract complex, FFM-GS) using in vitro and in vivo models for the development of improved materials of women’s menopausal symptoms. Ovariectomized rats were used and fed either the control diet or diet supplemented with FFM-GS 100 and 300 mg/kg b.w. The weight gain and dyslipidemia (high cholesterol, high low-density lipoprotein cholesterol and hypertriglyceridemia) symptoms were alleviated in the ovariectomized rats. On the other hand, diet supplementation of FFM-GS decreased significantly the weight gain and dyslipidemia symptoms in ovariectomized rats. In addition, the serum alkaline phosphatase (ALP) and osteocalcin levels, and bone morphometric measurements markers [bone mineral density, percent bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp)] were recovered in ovariectomized rats supplemented with FFM-GS. The FFM-GS treatment increased the mineralization and mRNA expression levels of osteocalcin, ALP, IGF-1, and estrogen receptor in co-culture cells with MC3T3-E1 cells and femoral bone marrow from C57BL/6 mice. Therefore, FFM-GS has a potential positive effect on improving female postmenopausal symptoms, including weight gain, dyslipidemia, and osteoporosis.
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KEYWORD
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grape seed extrac, postmenopausal symptoms, ovariectomy
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